created by: Maxime Bos
DESCRIPTION OF DATA
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File name: CAC1000G_EA_AA_FINAL.txt
This data file contains the summary statistics of the combined European and African American ancestry GWAS for coronary artery calcification after filtering.
Meta-analysis performed by: Maryam Kavousi (March 16 2018)
Meta-analysis file filtered by: Maxime Bos and Doris Wong (July 1 2020 and Oct 12 2021)
Meta-analysis file finalized by: Clint Miller (Oct 12 2021)
FILTERING STEPS
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Exclusions:
MAF < 0.01
heterogeneity I2 ≥70%
ncohorts < 4
SumEA=0
SumAA=0
chr=X
SNP INFO
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SNPs included before filtering - 19659744
SNPs included after filtering - 8586047
VARIABLE NAMES AND INFORMATION
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MarkerName - SNP name consisting of chromosome and position number
rsID - Marker rsID number
Chr - Chromosome
Pos - Position number (base pair)
Allele1 - Effect allele (First allele for this marker at first occurence)
Allele2 - Non-effect allele (Second allele for this marker at first occurence)
Freq1 - Effect allele frequency
FreqSE - Effect allele frequency standard error
MinFreq - Effect allele minimum frequency
MaxFreq - Effect allele maximum frequency
Effect - Effect estimate
StdErr - Standard error
Pvalue - P-value
Direction - Summary of effect direction for each study cohort, with (-), (+), or (?) - (not reported)
HetISq - I^2 statistic of measured heterogeneity on scale of 0-100%
HetChiSq - Chi-squared statistic in simple test of heterogeneity
HetDf - Degrees of freedom for heterogeneity statistic
HetPval - P-value for heterogeneity statistic
N - Number of participants
ncohorts - Total nummber of cohorts
AA - Direction of effect for AA cohorts
EA - Direction of effect for EA cohorts
AASum - Number of AA cohorts
EASum - Number of EA cohorts